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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC7
All Species:
11.21
Human Site:
S228
Identified Species:
30.83
UniProt:
O00311
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00311
NP_001127891.1
574
63888
S228
E
R
C
S
Q
N
K
S
H
I
I
T
G
N
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097186
574
63766
S228
E
R
C
S
Q
N
K
S
H
I
I
T
G
N
K
Dog
Lupus familis
XP_537080
756
83548
S409
E
S
C
S
Q
N
K
S
H
V
I
T
G
N
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0H0
564
62734
S218
E
A
Q
Q
E
D
C
S
R
N
K
Y
H
G
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521163
410
45484
V71
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
Chicken
Gallus gallus
XP_422347
564
62394
P222
G
S
Y
S
Q
S
N
P
N
I
A
L
G
N
G
Frog
Xenopus laevis
NP_001081878
483
53563
H144
I
H
S
F
G
I
V
H
R
D
V
K
P
S
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785538
591
65818
R248
V
L
H
H
D
T
P
R
P
P
Q
A
R
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06243
507
58302
T167
I
H
R
D
I
K
P
T
N
F
L
F
N
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.8
68.9
N.A.
78
N.A.
N.A.
61.3
67.2
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
Protein Similarity:
100
N.A.
97.7
71.5
N.A.
84.8
N.A.
N.A.
65.6
78.7
66.9
N.A.
N.A.
N.A.
N.A.
N.A.
54.4
P-Site Identity:
100
N.A.
100
86.6
N.A.
13.3
N.A.
N.A.
6.6
33.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
100
93.3
N.A.
26.6
N.A.
N.A.
6.6
46.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
0
0
0
0
12
0
12
12
0
0
0
% A
% Cys:
0
0
34
0
12
0
12
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
12
12
12
0
0
0
12
0
0
12
0
0
% D
% Glu:
45
12
0
0
12
0
0
0
0
0
0
0
0
0
12
% E
% Phe:
0
0
0
12
0
0
0
0
0
12
0
12
0
0
0
% F
% Gly:
12
0
0
0
12
0
0
0
0
12
12
0
45
12
12
% G
% His:
0
23
12
12
0
0
0
12
34
0
0
0
12
0
0
% H
% Ile:
23
0
0
0
12
12
0
0
0
34
34
0
0
0
0
% I
% Lys:
0
0
0
0
0
12
34
0
0
0
12
12
0
12
34
% K
% Leu:
0
12
12
0
0
12
0
0
0
0
12
12
0
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
34
12
0
23
12
0
0
12
56
23
% N
% Pro:
0
0
0
0
0
0
23
12
12
12
0
0
12
0
0
% P
% Gln:
0
0
12
23
45
0
0
0
0
0
12
12
0
0
0
% Q
% Arg:
0
23
12
0
0
0
0
12
23
0
0
0
12
0
0
% R
% Ser:
0
23
12
45
0
12
0
45
0
0
0
0
0
12
0
% S
% Thr:
0
0
0
0
0
12
12
12
0
0
0
34
0
0
0
% T
% Val:
12
0
0
0
0
0
12
12
0
12
12
0
0
0
23
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
0
0
0
0
0
12
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _